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Ultrastructural pathology of human T-cell lymphotropic virus type I encephalomyelopathy in a white patient with adult T-cell leukemia/lymphoma

Ultrastructural Pathology, ISSN: 0191-3123, Vol: 18, Issue: 5, Page: 511-518
1994
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Article Description

A white patient with human T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell leukemia/lymphoma for 10 years died 4 months after the onset of spastic myelopathy. Ultrastructurally, the neuropathologic findings consisted of dystrophic neurites (spheroids) filled with neurofilaments or electron-dense bodies, intense astrocytic reaction with abundant formation of corpora amylacea, and multilamellar bodies. Demyelination and spongiform change were absent. Viruslike particles resembling HTLV-I were detected adjacent to brain endothelial cells. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Bibliographic Details

Pawel P. Liberski; Pamela Rodgers-Johnson; Richard Yanagihara; Pedro Piccardo; Carlos A. Mora; Clarence J. Gibbs; D. Carleton Gajdusek; James W. Lee; Barnett S. Kramer

Informa UK Limited

Biochemistry, Genetics and Molecular Biology; Medicine

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