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Intestinal extramedullary plasmacytoma associated with amyloid deposition in three dogs: An ultrastructural and immunoelectron microscopic study

Ultrastructural Pathology, ISSN: 0191-3123, Vol: 22, Issue: 5, Page: 393-400
1998
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Article Description

Samples from rectal plasmacytoma in three adult dogs that were diagnosed by light microscopy and immunohistochemistry were examined by electron microscopy. The most common cell type had typical plasmacytoid features. A second cell type was a plasmacytoid giant cell with single or multiple eccentric nuclei, irregular nuclear membrane, abundant and dilated rough endoplasmic reticulum, and numerous electron-dense granules. The third cell type was a histiocytic giant cell that intermingled with plasmacytoid cells. All three tumors had abundant amyloid, mainly in the interstitium but also within histiocytic cells and less commonly in plasma cells or plasmacytoid giant cells. Extracellular and intracellular amyloid fibrils and the contents of membrane-bound electron-dense bodies of plasma cells reacted with antibody to γ-light chain of immunoglobulins by immunogold staining.

Bibliographic Details

José A. Ramos-Vara; Mutsuo Takahashi; Tokuhiro Ishihara; Margaret A. Miller; Lanny W. Pace; Donna Craft; Ralph Common; Gary L. Watson

Informa UK Limited

Medicine; Biochemistry, Genetics and Molecular Biology

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