Topical delivery of enoxaparin using nanostructured lipid carrier
Journal of Microencapsulation, ISSN: 0265-2048, Vol: 30, Issue: 7, Page: 709-715
2013
- 28Citations
- 35Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations28
- Citation Indexes28
- 28
- CrossRef12
- Captures35
- Readers35
- 35
Article Description
Topical application of enoxaparin (ENX; low molecular weight heparin) prevents the occurrence of thrombosis at traumatic anastomosis site. Particulate carrier system like nanostructured lipid carriers (NLCs) could notably improve skin penetration of ENX. ENX-loaded NLCs were prepared by the solvent diffusion technique. The effect of formulation and process variables on the physicochemical properties of prepared NLCs was studied and characterized. In vitro skin permeation studies revealed better passage of enoxaparin by NLCs than of plain drug. The in vivo skin retention was monitored by fluorescence microscopy. The prepared NLCs when stored for 120 days were found to be more stable at 4 ± 2 °C than room temperature. The overall results of the study demonstrated the importance of carrier composition on the physicochemical properties, morphology, skin irritation and consequently the effectiveness of particulate system as a vehicle for topical delivery of enoxaparin. © 2013 Informa UK Ltd. All rights reserved.
Bibliographic Details
Informa UK Limited
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