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Controlled release of transforming growth factor-β from lipid-based microcylinders

Journal of Microencapsulation, ISSN: 0265-2048, Vol: 12, Issue: 3, Page: 247-254
1995
  • 36
    Citations
  • 0
    Usage
  • 15
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    36
    • Citation Indexes
      36
  • Captures
    15

Article Description

The release of transforming growth factor-β (TGF-β from a lipid microstructure has been demonstrated. Lipid microcylinders, with dimensions of 100 × 0.5 μm and composed of a diacetylenic lipid, have been loaded with 25 ng TGF-βmg lipid. Physical and bioactive release characteristics of TGF-β from these microcylinders and from microcylinders embedded in an agarose hydrogel are reported. Release of TGF-β from lipid microcylinders follows typical diffusionlimited characteristics, where 10-12% of the TGF is released in the first 10h at 37°C. The release rate is shown to be temperature controlled and dependent on the integrity of the lipid microcylinder. Immobilization of the lipid microcylinder in a hydrogel matrix composed of agarose and gelatin does not impair the diffusion of TGF-β from the lipid microcylinders. The utilization of microcylinders as release vehicles in wound repair is discussed. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Bibliographic Details

B. J. Spargo; A. S. Rudolph; R. O. Cliff; F. M. Rollwagen

Informa UK Limited

Chemical Engineering; Pharmacology, Toxicology and Pharmaceutics; Chemistry

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