Controlled release of transforming growth factor-β from lipid-based microcylinders
Journal of Microencapsulation, ISSN: 0265-2048, Vol: 12, Issue: 3, Page: 247-254
1995
- 36Citations
- 15Captures
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Article Description
The release of transforming growth factor-β (TGF-β from a lipid microstructure has been demonstrated. Lipid microcylinders, with dimensions of 100 × 0.5 μm and composed of a diacetylenic lipid, have been loaded with 25 ng TGF-βmg lipid. Physical and bioactive release characteristics of TGF-β from these microcylinders and from microcylinders embedded in an agarose hydrogel are reported. Release of TGF-β from lipid microcylinders follows typical diffusionlimited characteristics, where 10-12% of the TGF is released in the first 10h at 37°C. The release rate is shown to be temperature controlled and dependent on the integrity of the lipid microcylinder. Immobilization of the lipid microcylinder in a hydrogel matrix composed of agarose and gelatin does not impair the diffusion of TGF-β from the lipid microcylinders. The utilization of microcylinders as release vehicles in wound repair is discussed. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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