Whole body hyperthermia and heat-sensitizing drugs: A pilot study in canine lymphoproliferative disease
International Journal of Hyperthermia, ISSN: 0265-6736, Vol: 3, Issue: 3, Page: 187-198
1987
- 8Citations
- 4Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations8
- Citation Indexes8
- CrossRef8
- Captures4
- Readers4
Article Description
Thirteen dogs were entered into a pilot study to assess the toxicities associated with polyamine biosynthetic enzyme inhibitors as heat sensitizing drugs and whole body hyperthermia either alone or in combination. Disease-free and tumour-bearing animals were entered in an effort to assess the response of canine lymphoproliferative disorders as well. Conclusions reached were as follows. (1) A large tumour burden precludes treatment. (2) Liver involvement and decreased platelet numbers would appear to offer a grave prognosis for survival and should be assessed closely in determining eligibility. (3) Polyamine biosynthetic enzyme inhibitors and whole body hyperthermia appear to be tumouricidal alone or in combination, although less effective and with greater toxicities than accepted chemotherapeutic regimens. (4) Heat sensitization in vivo has not yet been demonstrated. © 1987 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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