Temperature distribution during radiant heat whole-body hyperthermia: Experimental studies in the dog
International Journal of Hyperthermia, ISSN: 0265-6736, Vol: 3, Issue: 3, Page: 199-208
1987
- 16Citations
- 7Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations16
- Citation Indexes16
- 16
- CrossRef10
- Captures7
- Readers7
Article Description
A radiant heat system for whole-body hyperthermia (WBH) has been safely and effectively used in mice, pigs and humans. This report details our adaptation of this methodology to dogs. Mongrel dogs were used to study different anaesthesia methods including spontaneous ventilation with or without intubation, as well as mechanical ventilation. Temperature distribution was studied during 42°C WBH; intraabdominal, liver, bone marrow, brain, rectal, lung, oesophageal and skin temperatures were monitored. When a target temperature of 42°C was achieved, temperature gradients between organs were minimal with the possible exception of bone marrow. Results obtained are consistent with the concept that the liver is a major source of metabolic heat production. The establishment of a dog model for WBH allows for physiological and pharmacological studies. The existence of spontaneous neoplasms should promote the use of this species for trials combining hyperthermia with other modalities. © 1987 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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