Studies on methotrexate effects on testicular steroidogenesis in rats
Endocrine Research, ISSN: 0743-5800, Vol: 26, Issue: 2, Page: 247-262
2000
- 33Citations
- 7Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations33
- Citation Indexes33
- 33
- CrossRef17
- Captures7
- Readers7
Article Description
The effects of single dose, 4 consecutive days, 4 and 8 weekly doses of methotrexate (MTX) treatment (3 mg/kg body weight, intramuscularly) with and without leucovorin (LCN) supplementation (0.3 mg/kg body weight, intramuscularly) on serum testosterone titres, total, free and esterified cholesterol concentrations and steroidogenic enzymes, viz. 3β- and 17β- hydroxy steroid dehydrogenase activities were studied in adult albino rats. MTX treatment caused a marked reduction in serum testosterone titres in all the treatment groups in a duration-dependent manner. LCN supplementation did not restore serum testosterone titres to normalcy. Total and free cholesterol concentrations remained unaltered in both MTX and MTX + LCN treated groups. On the otherhand, a marked increase in esterified cholesterol concentration was evident only in weekly dose treatment groups. The specific activities of 3β- and 17β-hydroxy steroid dehydrogenase were markedly diminished in both MTX and MTX + LCN treated groups. The results suggest the inhibitory effect of MTX on steroidogenisis.
Bibliographic Details
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