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The evaluation of involvement of angiotensin II, its receptors, and androgen receptor in endometrial cancer

Gynecological Endocrinology, ISSN: 1473-0766, Vol: 31, Issue: 1, Page: 1-6
2015
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Article Description

Endometrial cancer (EC) is the most common gynecological malignancy. Alterations of angiogenic factors including angiotensin (AngII) or VEGF are observed in EC. Expression of angiotensin receptor 1 (AT1) is correlated with EC. Moreover, the expression of VEGF is up-regulated by AngII. Androgens are involved in the pathogenesis of EC. Genetic variations in androgen receptor (AR) gene may increase EC risk. This review proved strong correlation among EC, AngII, its receptors and AR, where AT influence on AR and, as a result, induce the expression of genes related to carcinogenesis.

Bibliographic Details

Matysiak, Zuzanna Elżbieta; Ochędalski, Tomasz; Piastowska-Ciesielska, Agnieszka Wanda

Informa UK Limited

Medicine; Biochemistry, Genetics and Molecular Biology

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