Influence of obesity and menopausal status on serum leptin, cholecystokinin, galanin and neuropeptide Y levels
Gynecological Endocrinology, ISSN: 0951-3590, Vol: 14, Issue: 3, Page: 196-203
2000
- 63Citations
- 20Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations63
- Citation Indexes63
- 63
- CrossRef46
- Captures20
- Readers20
- 20
Article Description
Obesity occurs in 60% of women after menopause and is characterized by an excess of adipose tissue that depends on several orexigenic (neuropeptide Y (NPY) stimulates carbohydrate ingestion, galanin stimulates fat intake) and anorectic (leptin, cholecystokinin (CCK)) factors. Both leptin and insulin can reduce hypothalamic NPY production and secretion. Behavior related to the consumption of food is probably attributed to the NPY-galanin signalling route. We investigated basal levels of serum leptin, CCK, galanin and NPY in 16 non-obese premenopausal women (body mass index (BMI) 34.6 ± 1.3 SD) and in ten obese postmenopausal women (BMI 34.7 ± 1.5 SD) to determine the relationship between obesity, menopause and these neuropeptides. Obese premenopausal women and three-fold elevations of serum leptin (32.1 ± 3.2 ng/ml) in comparison to non-obese premenopausal women (10.3 ± 1.5 ng/ml), but similar levels to those in obese postmenopausal women (35.3 ± 4.1 ng/ml). In all 44 patients and in both subgroups of premenopausal and postmenopausal women, serum leptin exhibited a strong positive correlation with BMI (r = 0.8692, p < 0.001; r = 0.8803, p = 0.001; r = 0.8184, p = 0.001, respectively). Serum galanin values showed a statistically significant increment in the obese postmenopausal group (51.1 ± 8.1 pg/ml) compared to both premenopausal groups: the non-obese (34.9 ± 5.8 pg/ml) and the obese (36.0 ± 5.5 pg/ml). Non-obese menstruating women demonstrated NPY levels (175.0 ± 12.8 pg/ml) significantly higher than those of obese premenopausal women (126.0 ± 12.1 pg/ml) and obese postmenopausal women (138.1 ± 15.4 pg/ml). CCK values showed no differences between non-obese and obese pre- and postmenopausal groups. Basal insulin values were elevated in both obese groups compared to non-obese premenopausal women. Significantly increased leptin and galanin levels in postmenopausal obese women coupled with decreased NPY levels revealed some changes in the neuropeptides regulating eating behavior, which may be the reason for the onset of postmenopausal obesity.
Bibliographic Details
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know