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Effect of alginate and calcium on secretion of il-1 by immobilized swiss peritoneal macrophages

Biomaterials, Artificial Cells and Immobilization Biotechnology, ISSN: 1055-7172, Vol: 21, Issue: 3, Page: 353-358
1993
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Article Description

Murine peritoneal macrophages were immobilized in calcium alginate gel macrobeads, using 1,5 % Na-alginate and 50 mM CaCl2. Secretion of IL-1 by immobilized macrophages increased during time and reached 10 fold than IL-1 quantities secreted by adherent macrophages. Calcium and alginate individually enhance production of IL-1 by macrophages and act in synergy when macrophages are immobilized in calcium alginate matrix. © 1993, Informa UK Ltd. All rights reserved.

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