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Prolongation Of The Intravascular Retention Of Hemoglobin Modified With A Long-Chain Fatty Acid Derivative1

Artificial Cells, Blood Substitutes, and Biotechnology, ISSN: 1532-4184, Vol: 22, Issue: 1, Page: 27-42
1994
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Article Description

To develop hemoglobin (Hb) derivatives with an increased circulatory half-life, Hb was chemically modified with long chain fatty acid analogs.One compound, sodium 1-hexadecyl 6-(2-iodoacetamido)hexyl phosphate, specifically modified the Cys-93p residues of human hemoglobin (HbA) as determined by sulfhydryl titration analysis.The resulting modified Hb derivative, FAHbA, was isolated and was shown to have a two-fold longer circulatory half-life than native HbA in a rat low-dose acute transfusion model. © 1994, Informa UK Ltd. All rights reserved.

Bibliographic Details

Scott A. Fowler; Mark Andracki; Gerald Hurst; Vidya A. Honkan; Joseph Waldorf; Dee Ann Casteel

Informa UK Limited

Biochemistry, Genetics and Molecular Biology; Engineering

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