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DNA adducts of ortho-toluidine in human bladder

Biomarkers, ISSN: 1354-750X, Vol: 16, Issue: 2, Page: 120-128
2011
  • 25
    Citations
  • 0
    Usage
  • 14
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    25
  • Captures
    14
  • Mentions
    1
    • News Mentions
      1
      • News
        1

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Dosing of Carcinogenic Complexes After Anesthesia With Intrathecal Hyperbaric Prilocaine.

STUDY INFORMATION OFFICIAL TITLE: Dosing of Carcinogenic Complexes Such as Urinary O-toluidine and Hemoglobin Adducts From O-toluidine in Blood After Intrathecal Administration of 50 mg

Article Description

Background: 4-Aminobiphenyl (4-ABP) and o-toluidine are known human bladder carcinogens, but only 4-ABP-releasing DNA adducts are known. Methods: Determination of 4-ABP and o-toluidine-releasing DNA adducts in epithelial and submucosal bladder tissues of sudden death victims (SDV: n=46), and bladder tumours (n=12) by gas chromatography/mass spectrometry. Results: Above background, 4 and 11 of 12 tumour samples contained adducts of 4-ABP (0.057±0.125fmol/μg DNA) and o-toluidine (8.72±4.49fmol/μg DNA), respectively. Lower adduct levels were present in both epithelial and submucosal bladder tissues of SDV (4-ABP: 0.011±0.022 and 0.019±0.047fmol/μg DNA; o-toluidine: 0.24±0.63 and 0.27±0.70fmol/μg DNA). Conclusion: Detection of o-toluidine-releasing DNA adducts support the carcinogenicity of o-toluidine in the human bladder. © 2011 Informa UK, Ltd.

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