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Evaluation of oxidative stress and DNA damage in traffic policemen exposed to vehicle exhaust

Biomarkers, ISSN: 1354-750X, Vol: 18, Issue: 5, Page: 406-411
2013
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Article Description

Objective: We aimed to study the genotoxic effects in traffic police who are occupationally exposed due to higher free radical generation. Methods: Ambient and breathing zone air samples were analyzed blood samples were collected for analysis of antioxidant enzymes Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx) and free radicals-nitric oxide (NO) and malondialdehyde (MDA) levels using a spectrophotometer. DNA damage was measured with the comet assay. Results: Higher levels of benzene (BZ), toluene (TOL), carbon monoxide (CO), benzo([a])pyrene (BaP) and sulfur dioxide (SO2) was observed in traffic police. Elevated levels of NO, MDA and comet tail length and lower SOD and GPx levels observed in traffic police. Conclusion: The studied biomarkers, related to oxidative stress and DNA damage positively correlated in traffic police exposed to environmental air pollutants. © 2013 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted.

Bibliographic Details

Prasad, Badabagni Siva; Vidyullatha, Peddireddy; Venkata, Rekhadevi Perumalla; Tirumala, Vani Gudimella; Varre, Sreedevi; Penagaluru, Usha Rani; Grover, Paramjit; Mundluru, Hema Prasad; Penagaluru, Pardhanandana Reddy

Informa UK Limited

Biochemistry, Genetics and Molecular Biology; Environmental Science

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