Ultrastructural studies in langerhans cell histiocytosis: A search for evidence of viral etiology
Fetal and Pediatric Pathology, ISSN: 1551-3815, Vol: 14, Issue: 5, Page: 895-904
1994
- 24Citations
- 2Captures
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Metrics Details
- Citations24
- Citation Indexes24
- 24
- CrossRef17
- Captures2
- Readers2
Article Description
The ultrastructure oflesional cells in biopsy material from 50 cases of Langerhans cell histiocytosis (LCH) was studied for the effects of virus and/or cytokines. Viral "footprints,' which actually represent ultrastructural signs of the effects of cytokines on cells, were found in 76% of the cases. These were detected in lesional Langerhans cells, endothelial cells, and lymphocytes and consisted of tubuloreticular structures, cylindrical confronting cisternae, and curvilinear membranous formations. No virus particles or virus-specific cell products were found. These studies suggest that LCH cells are subject to cytokine stimulation but provide no evidence to implicate a virus in the disease process.. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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