Assessment the Effect of Ellagic Acid on 5-fluorouracil-induced Intestinal Mucositis and Diarrhea in Mice
Iraqi Journal of Pharmaceutical Sciences, ISSN: 2521-3512, Vol: 32, Issue: Suppl., Page: 33-41
2023
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Article Description
The intestinal mucositis is defined as the inflammation and ulceration in the -gastrointestinal tract wall and in some case in the -oral cavity that can be caused by treatment with antineoplastic drugs like 5-fluorouracil, irinotecan and others; since, the intestinal mucositis can in turn cause series of undesirable symptoms like severe diarrhea, abdominal pain, uncomfortable stomach and other symptoms. The current study was designed to evaluate the effects of ellagic acid against 5-fluorouracil-induced intestinal mucositis and diarrhea in mice. Induction of the intestinal mucositis was induced by intraperitoneal-injection of 50mg/kg 5-fluorouracil daily for 4 consecutive days and then, assessment of intestinal mucositis was performed by measuring the level of the antioxidant enzyme [superoxide dismutase (SOD)], and levels of some pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-α); and the lipid peroxidation product, the malondialdehyde (MDA) in tissue homogenate, in addition to the histopathological scoring; moreover, the potential action of ellagic acid was further supported by histopathological examination. Pretreatment of mice with 10mg/kg ellagic acid produced significant improvement in the level of antioxidant enzymes, pro inflammatory cytokines, lipid peroxidation product in the tissue homogenate, and the histopathological scoring and examination compared to such levels in the induction/5-fluorouracil group. Results suggested that ellagic acid is effective in protecting mice from intestinal mucositis induced by 5-fluorouracil.
Bibliographic Details
College of Pharmacy University of Baghdad
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