Goat Acetyl-Coenzyme A Carboxylase α: Molecular Characterization, Polymorphism, and Association with Milk Traits
Journal of Dairy Science, ISSN: 0022-0302, Vol: 90, Issue: 2, Page: 1039-1043
2007
- 41Citations
- 31Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations41
- Citation Indexes40
- 40
- CrossRef39
- Policy Citations1
- 1
- Captures31
- Readers31
- 31
Article Description
Acetyl-coenzyme A carboxylase α (ACACA), the major regulatory enzyme of fatty acid biosynthesis, catalyzes the conversion of acetyl-CoA to malonyl-CoA. We have sequenced 5.5 kb of the goat ACACA cDNA in 18 individuals. The translated cDNA sequence encodes 1,832 AA and shares a high AA identity (99%) with the ovine and bovine ACACA orthologous sequences. One silent single nucleotide polymorphism was identified at exon 45 (C5493T). The genotyping of this polymorphism in 4 goat breeds, Murciano-Granadina, Teramana, Majorera, and Malagueña, showed that it was segregating in all 4 breeds at variable frequencies. In addition, a mixed animal model was used to evaluate the association of C5493T genotypes with milk traits. Results from this study show that the C5493T mutation was suggestively associated with fat yield, lactose content, and somatic cell count.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0022030207715904; http://dx.doi.org/10.3168/jds.s0022-0302(07)71590-4; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34247880355&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/17235183; http://linkinghub.elsevier.com/retrieve/pii/S0022030207715904; https://linkinghub.elsevier.com/retrieve/pii/S0022030207715904; http://dx.doi.org/10.3168/jds.s0022-0302%2807%2971590-4; https://dx.doi.org/10.3168/jds.s0022-0302%2807%2971590-4
American Dairy Science Association
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