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Bone morphogenetic proteins in anterior lumbar interbody fusion: old techniques and new technologies. Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2004.

Journal of neurosurgery. Spine, ISSN: 1547-5654, Vol: 1, Issue: 3, Page: 254-260
2004
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Review Description

OBJECT: The author reports the clinical and radiographic outcomes obtained in three prospective multicenter clinical trials in which recombinant human bone morphogenetic protein-2 (rhBMP-2) was used in anterior lumbar interbody fusion (ALIF). METHODS: Stand-alone interbody fusion cages were used, and supplemental fixation was not performed as part of the study protocol. Patients were randomly assigned to one of two ALIF groups: one in which autologous iliac crest bone graft was used (control) and one in which an rhBMP-2-coated absorbable collagen sponge was placed (investigational group). In all patients who underwent rhBMP-2-augmented fusion, imaging demonstrated evidence of bone induction and early incorporation of the cortical allografts. Overall, more expedient clinical improvements and higher success rates were observed in the rhBMP-2 group. CONCLUSIONS: In these studies it was shown that rhBMP-2 is a safe and effective material for facilitating ALIF and for decreasing pain and improving clinical outcomes.

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