In vivo proton MR spectroscopy evaluation of pyogenic brain abscesses: A report of 194 cases
American Journal of Neuroradiology, ISSN: 0195-6108, Vol: 31, Issue: 2, Page: 360-366
2010
- 71Citations
- 52Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations71
- Citation Indexes70
- 70
- CrossRef47
- Policy Citations1
- Policy Citation1
- Captures52
- Readers52
- 52
Article Description
BACKGROUND AND PURPOSE: The combination of nonspecific clinical findings and similarities in morphologic appearances on imaging often makes it difficult to distinguish abscesses from other brain lesions. We present a retrospective analysis of in vivo H-MR spectroscopy data for characterization of the etiology of the brain abscess based on the established criteria and demonstrate the sensitivity and specificity of metabolite markers assigned to specific bacterial groups defined by the microbial culture in 194 patients. MATERIALS AND METHODS: Conventional MR imaging and in vivo H-MR spectroscopy data were evaluated from patients with pyogenic brain abscesses, with ages ranging from 3 to 60 years. Imaging and H-MR spectroscopy were performed on a 1.5T scanner. After MR imaging was performed and analyzed, pus aspirates were obtained in all patients. The causative organisms were confirmed by pus cultures. RESULTS: Resonance of AAs with or without other metabolites on in vivo H-MR spectroscopy was observed in 80% of abscesses, with a sensitivity and specificity of 0.72 and 0.30, respectively. Most obligate anaerobes and some facultative anaerobes showed the presence of Lac/Lip, AAs, and Ac with or without Suc. Mostly obligate aerobes or facultative anaerobes showed the presence of Lac and AAs, with or without lipids. CONCLUSIONS: The presence of AAs on in vivo H-MR spectroscopy is a sensitive marker of pyogenic abscess, but its absence does not rule out a pyogenic etiology. The presence of Ac with or without Suc favors an anaerobic bacterial origin of the abscess; however, this may also be seen in some of the abscesses secondary to facultative anaerobes.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=76749089623&origin=inward; http://dx.doi.org/10.3174/ajnr.a1835; http://www.ncbi.nlm.nih.gov/pubmed/19797788; http://www.ajnr.org/lookup/doi/10.3174/ajnr.A1835; http://www.ajnr.org/cgi/doi/10.3174/ajnr.A1835; https://syndication.highwire.org/content/doi/10.3174/ajnr.A1835; https://dx.doi.org/10.3174/ajnr.a1835; https://www.ajnr.org/content/31/2/360
American Society of Neuroradiology (ASNR)
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