Meta-analysis: Low-dose intake of vitamin e combined with other vitamins or minerals may decrease all-cause mortality

It has been suggested that vitamin E alone or combined with other vitamins or minerals can prevent oxidative stress and slow oxidative injury-related diseases, such as cardiovascular disease and cancer. A comprehensive search of PubMed/MEDLINE, EMBASE and the Cochrane Library was performed. Relative risk was used as an effect measure to compare the intervention and control groups. A total of 33 trials were included in the metaanalysis. Neither vitamin E intake alone (RR51.01; 95% CI, 0.97 to 1.04; p50.77) nor vitamin E intake combined with other agents (RR50.97; 95% CI, 0.89 to 1.06; p50.55) was correlated with all-cause mortality. Subgroup analyses revealed that low-dose vitamin E supplementation combined with other agents is associated with a statistically significant reduction in all-cause mortality (RR50.92; 95% CI, 0.86 to 0.98; p50.01), and vitamin E intake combined with other agents is associated with a statistically significant reduction in mortality rates among individuals without probable or confirmed diseases (RR50.92; 95% CI, 0.86 to 0.99; p50.02). Neither vitamin E intake alone nor combined with other agents is associated with a reduction in all-cause mortality. But a low dose (,400 IU/d) of vitamin E combined with other agents is correlated with a reduction in all-cause mortality, and vitamin E intake combined with other agents is correlated with a reduction in the mortality rate among individuals without probable or confirmed diseases.