Rapid determination of HLA B*07 ligands from the West Nile virus NY99 genome
Emerging Infectious Diseases, ISSN: 1080-6040, Vol: 7, Issue: 4, Page: 706-713
2001
- 29Citations
- 23Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations29
- Citation Indexes29
- 29
- CrossRef19
- Captures23
- Readers23
- 23
Article Description
Defined T-cell epitopes for West Nile (WN) virus may be useful for developing subunit vaccines against WN virus infection and diagnostic reagents to detect WN virus-specific immune response. We applied a bioinformatics (EpiMatrix) approach to search the WN virus NY99 genome for HLA B*07 restricted cytotoxic T-cell (CTL) epitopes. Ninety-five of 3,433 WN virus peptides scored above a predetermined cutoff, suggesting that these would be likely to bind to HLA B*07 and would also be likely candidate CTL epitopes. Compared with other methods for genome mapping, derivation of these ligands was rapid and inexpensive. Major histocompatibility complex ligands identified by this method may be used to screen T cells from WN virus-exposed persons for cell-mediated response to WN virus or to develop diagnostic reagents for immunopathogenesis studies and epidemiologic surveillance.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0034845973&origin=inward; http://dx.doi.org/10.3201/eid0704.017419; http://dx.doi.org/10.3201/eid0704.010419; http://www.ncbi.nlm.nih.gov/pubmed/11585536; http://wwwnc.cdc.gov/eid/article/7/4/01-0419_article.htm; http://wwwnc.cdc.gov/eid/article/7/4/01-7419_article.htm; https://dx.doi.org/10.3201/eid0704.010419; https://wwwnc.cdc.gov/eid/article/7/4/01-7419_article; https://dx.doi.org/10.3201/eid0704.017419
Centers for Disease Control and Prevention (CDC)
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