Interspecies transmission of reassortant swine influenza a virus containing genes from swine influenza A(H1N1)pdm09 and A(H1N2) viruses
Emerging Infectious Diseases, ISSN: 1080-6059, Vol: 26, Issue: 2, Page: 273-281
2020
- 16Citations
- 29Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations16
- Citation Indexes14
- CrossRef14
- 11
- Policy Citations2
- Policy Citation2
- Captures29
- Readers29
- 29
- Mentions1
- News Mentions1
- News1
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INTRODUCTION Viruses circulating among wild and domestic animal populations are a potential risk to both animal and human health. Every year, epizootic infections cause economic
Article Description
Influenza A(H1N1)pdm09 (pH1N1) virus has become established in swine in the United Kingdom and currently co-circulates with previously enzootic swine influenza A virus (IAV) strains, including avian-like H1N1 and human-like H1N2 viruses. During 2010, a swine influenza A reassortant virus, H1N2r, which caused mild clinical disease in pigs in the United Kingdom, was isolated. This reassortant virus has a novel gene constellation, incorporating the internal gene cassette of pH1N1-origin viruses and hemagglutinin and neuraminidase genes of swine IAV H1N2 origin. We investigated the pathogenesis and infection dynamics of the H1N2r isolate in pigs (the natural host) and in ferrets, which represent a human model of infection. Clinical and virologic parameters were mild in both species and both intraspecies and interspecies transmission was observed when initiated from either infected pigs or infected ferrets. This novel reassortant virus has zoonotic and reverse zoonotic potential, but no apparent increased virulence or transmissibility, in comparison to pH1N1 viruses.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85078167526&origin=inward; http://dx.doi.org/10.3201/eid2602.190486; http://www.ncbi.nlm.nih.gov/pubmed/31961298; http://wwwnc.cdc.gov/eid/article/26/2/19-0486_article.htm; https://dx.doi.org/10.3201/eid2602.190486; https://wwwnc.cdc.gov/eid/article/26/2/19-0486_article
Centers for Disease Control and Prevention (CDC)
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