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The expression of programmed death-ligand 1 and its association with histopathological grade, stage of disease, and occurrence of metastasis in breast cancer

Breast Disease, ISSN: 1558-1551, Vol: 40, Issue: S1, Page: S71-S76
2021
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Article Description

INTRODUCTION: Programmed death ligand 1 (PD-L1) plays a role in tumor escape and progression by inactivating T lymphocytes. The aim of the study reported here was to determine the relationship between the expression of PD-L1 and histopathological grade, stage of disease, and the occurrence of metastasis in breast cancer. METHODS: The observational cross-sectional study involved analyzing the expression of PD-L1 by immunohistochemistry. RESULTS: PD-LI was expressed in 43 of 60 patients with breast cancer (71.6%), mostly with a moderate histopathological grade (58.3%) and at an advanced stage (50%). Associations between the expression of PD-L1 and histopathological grade (p = 0.011), stage of disease (p = 0.009), and the occurrence of metastasis (p = 0.01) were significant, with an odds ratio of 5. CONCLUSION: The associations between the expression of PD-L1 and histopathological grade, disease stage, and occurrence of metastasis were all significant in cases of breast cancer in the sample. Those findings suggest that the expression of PD-L1 increases the progression of breast cancer.

Bibliographic Details

Agung Sindu Pranoto; Haryasena Haryasena; Prihantono Prihantono; Septiman Rahman; Daniel Sampepajung; Indra Indra; Salman Ardy Syamsu; Elridho Sampepajung; Berti Julian Nelwan; Muhammad Faruk; Andi Nilawati Usman

SAGE Publications

Medicine; Biochemistry, Genetics and Molecular Biology

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