Quantitative Differences in Ia Antigen Expression in the Spleens of 15I 5 - B Congenic and Inbred Chickens as Defined by a New Monoclonal Antibody
Poultry Science, ISSN: 0032-5791, Vol: 67, Issue: 11, Page: 1525-1535
1988
- 17Citations
- 3Captures
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Metrics Details
- Citations17
- Citation Indexes17
- CrossRef17
- 16
- Captures3
- Readers3
Article Description
A monoclonal antibody (MAb), designated P2M11, that detects a monomorphic determinant of chicken class II antigens was produced from the fusion of P3X63 myeloma cells with spleen cells from BALB/c mice immunized with chicken splenic lymphocytes. Flow cytometric analyses of lymphocytes from the SC and FP strains of chickens showed 30 to 50% staining of bursa cells, 15 to 20% staining cells, and less than 5% staining of thymus cells. Addition of MAb P2M11 to splenic T cell cultures stimulated with allogeneic cells or concanavalin A resulted in a significant inhibition of the T cell proliferation responses. Immunoprecipitation of 35 S-methionine-labeled spleen cell extracts using MAb P2M11 identified molecules with apparent molecular weights of approximately 28,000, 30,000, and 32,000 by sodium dodecyl-polyacryl-amide gel electrophoresis. Taken together, these data indicate that the antigens detected by MAb P2M11 are similar in cell distribution and structure to chicken Ia antigens encoded by B-L genes. Using this MAb, a strain difference was demonstrated in the tissue distribution of Ia antigen positive lymphocytes in the spleens but not the thymuses of 15I 5 - B congenic and inbred strains of chickens. This difference may be due to the genes associated with B -complex genes.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0032579119570559; http://dx.doi.org/10.3382/ps.0671525; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0024118797&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/2467275; https://linkinghub.elsevier.com/retrieve/pii/S0032579119570559; https://dx.doi.org/10.3382/ps.0671525
Elsevier BV
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