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Subunit-specific mechanisms of isoflurane-induced acute tonic inhibition in dentate gyrus granule neuron

Experimental Biology and Medicine, ISSN: 1535-3699, Vol: 249, Page: 10171
2024
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Studies from Tianjin Reveal New Findings on Experimental Biology and Medicine (Subunit-specific mechanisms of isoflurane-induced acute tonic inhibition in dentate gyrus granule neuron)

2024 NOV 08 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Daily News -- New study results on experimental

Article Description

Prolonged exposure to volatile anesthetics may raise the risk of developing cognitive impairment by acting on gamma-a Aminobutyric acid A receptors (GABAAR). The dentate gyrus plays an important role in the hippocampus and has a high potential for neural plasticity. However, it is unknown whether prolonged anesthesia induces a change in acute phasic or tonic inhibition in dentate gyrus granule cells (DGGCs) by acting on GABAAR. In order to verify the effects of volatile anesthetics on the current in DGGCs, a whole-cell patch was applied to record acute brain slices, and this study indicated that 4 h but not 2 h of isoflurane (ISO) exposure induced significantly larger tonic currents in DGGCs other than hippocampal CA1 pyramidal and thalamic relay neurons. Furthermore, this study demonstrated that the increased tonic current in DGGCs was dependent on the δ subunit-containing GABAARs by using transgenic δ subunit knockout mice. In conclusion, the δ subunit specific GABAAR is the key element that increased acute tonic inhibition in DGGCs of mice after prolonged ISO exposure, which may be one of the mechanisms of ISO neurotoxicity to the developing brain.

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