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Carbon dots nanozyme for anti-inflammatory therapy via scavenging intracellular reactive oxygen species

Frontiers in Bioengineering and Biotechnology, ISSN: 2296-4185, Vol: 10, Page: 943399
2022
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The Potential of Novel Synthesized Carbon Dots Derived Resveratrol Using One-Pot Green Method in Accelerating in vivo Wound Healing

Introduction Nanomaterials are a special class of materials with sizes ranging from 1 to 100 nanometers.1 Compared to traditional materials, nanomaterials exhibit significantly increased surface

Article Description

Developing an efficient antioxidant for anti-inflammatory therapy via scavenging reactive oxygen species (ROS) remains a great challenge owing to the insufficient activity and stability of traditional antioxidants. Herein, we explored and simply synthesized a biocompatible carbon dots (CDs) nanozyme with excellent scavenging activity of ROS for anti-inflammatory therapy. As expected, CDs nanozyme effectively eliminate many kinds of free radicals including OH, O, and ABTS•. Benefiting from multienzyme activities against ROS, CDs nanozyme can decrease the levels of pro-inflammatory cytokines, resulting in good anti-inflammatory effect. Taken together, this study not only sheds light on design of bioactive antioxidants but also broadens the biomedical application of CDs in the treatment of inflammation.

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