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Heterochromatin as an Important Driver of Genome Organization

Frontiers in Cell and Developmental Biology, ISSN: 2296-634X, Vol: 8, Page: 579137
2020
  • 53
    Citations
  • 0
    Usage
  • 181
    Captures
  • 5
    Mentions
  • 123
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    53
  • Captures
    181
  • Mentions
    5
    • Blog Mentions
      2
      • Blog
        2
    • References
      2
      • Wikipedia
        2
    • News Mentions
      1
      • News
        1
  • Social Media
    123
    • Shares, Likes & Comments
      123
      • Facebook
        123

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Review Description

Heterochromatin is a constituent of eukaryotic genomes with functions spanning from gene expression silencing to constraining DNA replication and repair. Inside the nucleus, heterochromatin segregates spatially from euchromatin and is localized preferentially toward the nuclear periphery and surrounding the nucleolus. Despite being an abundant nuclear compartment, little is known about how heterochromatin regulates and participates in the mechanisms driving genome organization. Here, we review pioneer and recent evidence that explores the functional role of heterochromatin in the formation of distinct chromatin compartments and how failure of the molecular mechanisms forming heterochromatin leads to disarray of genome conformation and disease.

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