Heterochromatin as an Important Driver of Genome Organization
Frontiers in Cell and Developmental Biology, ISSN: 2296-634X, Vol: 8, Page: 579137
2020
- 53Citations
- 181Captures
- 5Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations53
- Citation Indexes53
- CrossRef53
- 49
- Captures181
- Readers181
- 181
- Mentions5
- Blog Mentions2
- Blog2
- References2
- Wikipedia2
- News Mentions1
- News1
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Review Description
Heterochromatin is a constituent of eukaryotic genomes with functions spanning from gene expression silencing to constraining DNA replication and repair. Inside the nucleus, heterochromatin segregates spatially from euchromatin and is localized preferentially toward the nuclear periphery and surrounding the nucleolus. Despite being an abundant nuclear compartment, little is known about how heterochromatin regulates and participates in the mechanisms driving genome organization. Here, we review pioneer and recent evidence that explores the functional role of heterochromatin in the formation of distinct chromatin compartments and how failure of the molecular mechanisms forming heterochromatin leads to disarray of genome conformation and disease.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85091900127&origin=inward; http://dx.doi.org/10.3389/fcell.2020.579137; http://www.ncbi.nlm.nih.gov/pubmed/33072761; https://www.frontiersin.org/article/10.3389/fcell.2020.579137/full; https://dx.doi.org/10.3389/fcell.2020.579137; https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.579137/full
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