Mechanism of Action of Mesenchymal Stem Cell-Derived Exosomes in the Intervertebral Disc Degeneration Treatment and Bone Repair and Regeneration
Frontiers in Cell and Developmental Biology, ISSN: 2296-634X, Vol: 9, Page: 833840
2022
- 39Citations
- 50Captures
- 2Mentions
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- Citations39
- Citation Indexes39
- 39
- Captures50
- Readers50
- 50
- Mentions2
- Blog Mentions1
- Blog1
- News Mentions1
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Most Recent Blog
Mesenchymal Stem Cell Exosomes to Treat Disc Degeneration
First generation stem cell therapies involve sourcing immune privileged cells from sources such as umbilical cord blood, or a patient's own cells from fat tissue or similar, expanding the cells in culture, and then injecting them. Only minimal modifications are permitted to cells prior to transplantation in the US, before it would be classed as a therapy that must go through the IND process with t
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Umbilical Cord Stem Cell Lysate: A New Biologic Injectate for the Putative Treatment of Acute Temporomandibular Joint Inflammation
Introduction Degenerative diseases that affect the temporomandibular joint (TMJ) are characterized by loss of articular fibrocartilage, bone remodeling, and synovitis.1 Although the etiopathogenesis of TMJ
Review Description
Exosomes are extracellular vesicles formed by various donor cells that regulate gene expression and cellular function in recipient cells. Exosomes derived from mesenchymal stem cells (MSC-Exos) perform the regulatory function of stem cells by transporting proteins, nucleic acids, and lipids. Intervertebral disc degeneration (IDD) is one of the main causes of low back pain, and it is characterized by a decreased number of nucleus pulposus cells, extracellular matrix decomposition, aging of the annulus fibrosus, and cartilage endplate calcification. Besides, nutrient transport and structural repair of intervertebral discs depend on bone and cartilage and are closely related to the state of the bone. Trauma, disease and aging can all cause bone injury. However, there is a lack of effective drugs against IDD and bone injury. Recent MSC-Exos fine tuning has led to significant progress in the IDD treatment and bone repair and regeneration. In this review, we looked at the uniqueness of MSC-Exos, and the potential treatment mechanisms of MSC-Exos with respect to IDD, bone defects and injuries.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85123789466&origin=inward; http://dx.doi.org/10.3389/fcell.2021.833840; http://www.ncbi.nlm.nih.gov/pubmed/35096846; https://www.frontiersin.org/articles/10.3389/fcell.2021.833840/full; https://dx.doi.org/10.3389/fcell.2021.833840; https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.833840/full
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