Development of a rat model of lymphedema and the implantation of a collagen-based medical device for therapeutic intervention
Frontiers in Cardiovascular Medicine, ISSN: 2297-055X, Vol: 10, Page: 1214116
2023
- 6Citations
- 6Captures
- 1Mentions
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Metrics Details
- Citations6
- Citation Indexes6
- Captures6
- Readers6
- Mentions1
- News Mentions1
- 1
Most Recent News
Studies from Stanford University in the Area of Lymphedema Described (Development of a rat model of lymphedema and the implantation of a collagen-based medical device for therapeutic intervention)
2023 JUL 17 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Medical Devices Daily -- Investigators publish new report on lymphedema. According to
Article Description
Secondary lymphedema is a common condition among cancer survivors, and treatment strategies to prevent or treat lymphedema are in high demand. The development of novel strategies to diagnose or treat lymphedema would benefit from a robust experimental animal model of secondary lymphedema. The purpose of this methods paper is to describe and summarize our experience in developing and characterizing a rat hindlimb model of lymphedema. Here we describe a protocol to induce secondary lymphedema that takes advantage of micro computed tomography imaging for limb volume measurements and visualization of lymph drainage with near infrared imaging. To demonstrate the utility of this preclinical model for studying the therapeutic benefit of novel devices, we apply this animal model to test the efficacy of a biomaterials-based implantable medical device.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85177240539&origin=inward; http://dx.doi.org/10.3389/fcvm.2023.1214116; http://www.ncbi.nlm.nih.gov/pubmed/37469481; https://www.frontiersin.org/articles/10.3389/fcvm.2023.1214116/full; https://dx.doi.org/10.3389/fcvm.2023.1214116; https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1214116/full
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