Vascular and hormonal interactions in the adrenal gland
Frontiers in Endocrinology, ISSN: 1664-2392, Vol: 13, Page: 995228
2022
- 6Citations
- 17Captures
- 1Mentions
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Metrics Details
- Citations6
- Citation Indexes6
- Captures17
- Readers17
- 17
- Mentions1
- News Mentions1
- 1
Most Recent News
Researchers at Universite Paris Cite Publish New Study Findings on Endocrinology (Vascular and hormonal interactions in the adrenal gland)
2022 DEC 08 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Daily -- Researchers detail new data in endocrinology. According to
Review Description
Primary aldosteronism is the most common form of secondary arterial hypertension, due to excessive aldosterone production from the adrenal gland. Although somatic mutations have been identified in aldosterone producing adenoma, the exact mechanisms leading to increased cell proliferation and nodule formation remain to be established. One hypothesis is that changes in vascular supply to the adrenal cortex, due to phenomena of atherosclerosis or high blood pressure, may influence the morphology of the adrenal cortex, resulting in a compensatory growth and nodule formation in response to local hypoxia. In this review, we will summarize our knowledge on the mechanisms regulating adrenal cortex development and function, describe adrenal vascularization in normal and pathological conditions and address the mechanisms allowing the cross-talk between the hormonal and vascular components to allow the extreme tissue plasticity of the adrenal cortex in response to endogenous and exogenous stimuli. We will then address recent evidence suggesting a role for alterations in the vascular compartment that could eventually be involved in nodule formation and the development of primary aldosteronism.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85143392507&origin=inward; http://dx.doi.org/10.3389/fendo.2022.995228; http://www.ncbi.nlm.nih.gov/pubmed/36506065; https://www.frontiersin.org/articles/10.3389/fendo.2022.995228/full; https://dx.doi.org/10.3389/fendo.2022.995228; https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.995228/full
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