Sphingosine-1-Phosphate (S-1P) Promotes Differentiation of Naive Macrophages and Enhances Protective Immunity Against Mycobacterium tuberculosis
Frontiers in Immunology, ISSN: 1664-3224, Vol: 10, Page: 3085
2020
- 12Citations
- 24Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations12
- Citation Indexes12
- 12
- CrossRef4
- Captures24
- Readers24
- 24
Article Description
Sphingosine-1-phosphate (S-1P) is a key sphingolipid involved in the pathobiology of various respiratory diseases. We have previously demonstrated the significance of S-1P in controlling non-pathogenic mycobacterial infection in macrophages, and here we demonstrate the therapeutic potential of S-1P against pathogenic Mycobacterium tuberculosis (H37Rv) in the mouse model of infection. Our study revealed that S-1P is involved in the expression of iNOS proteins in macrophages, their polarization toward M1 phenotype, and secretion of interferon (IFN)-γ during the course of infection. S-1P is also capable of enhancing infiltration of pulmonary CD11b+ macrophages and expression of S-1P receptor-3 (S-1PR3) in the lungs during the course of infection. We further revealed the influence of S-1P on major signaling components of inflammatory signaling pathways during M. tuberculosis infection, thus highlighting antimycobacterial potential of S-1P in animals. Our data suggest that enhancing S-1P levels by sphingolipid mimetic compounds/drugs can be used as an immunoadjuvant for boosting immunity against pathogenic mycobacteria.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85079106745&origin=inward; http://dx.doi.org/10.3389/fimmu.2019.03085; http://www.ncbi.nlm.nih.gov/pubmed/32038629; https://www.frontiersin.org/articles/10.3389/fimmu.2019.03085/supplementary-material/10.3389/fimmu.2019.03085.s001; http://dx.doi.org/10.3389/fimmu.2019.03085.s001; https://www.frontiersin.org/article/10.3389/fimmu.2019.03085/full; https://dx.doi.org/10.3389/fimmu.2019.03085; https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.03085/full; https://dx.doi.org/10.3389/fimmu.2019.03085.s001; https://www.frontiersin.org/articles/10.3389/fimmu.2019.03085/full
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