EZH2 restricts Tcf7 DNA methylation and promotes T differentiation during acute viral infection
Frontiers in Immunology, ISSN: 1664-3224, Vol: 13, Page: 942465
2022
- 4Citations
- 1Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations4
- Citation Indexes4
- Captures1
- Readers1
Article Description
Follicular helper T (T) cells provide specialized help for B cells to ensure optimal humoral immunity. The histone methyltransferase EZH2, as a chromatin repressor, secures the T differentiation by promoting T lineage associated gene expression during acute viral infection, including Tcf7 and Bcl6. By using conditional deletion murine system, we observed that EZH2 ablation in CD4 T cells was accompanied by aberrant accumulation of DNA methyltransferases (DNMTs) DNMT1 and DNMT3B in T cells. And the loss of EZH2 promoted aggravation of DNA methylation status at Tcf7 locus. Therefore, our findings suggested that EZH2 plays an important role in maintenance of hypomethylation at Tcf7 locus thus affecting T differentiation during acute viral infection.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85136884849&origin=inward; http://dx.doi.org/10.3389/fimmu.2022.942465; http://www.ncbi.nlm.nih.gov/pubmed/36045674; https://www.frontiersin.org/articles/10.3389/fimmu.2022.942465/full; https://dx.doi.org/10.3389/fimmu.2022.942465; https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.942465/full
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