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RIPK1 in the inflammatory response and sepsis: Recent advances, drug discovery and beyond

Frontiers in Immunology, ISSN: 1664-3224, Vol: 14, Page: 1114103
2023
  • 14
    Citations
  • 0
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  • 17
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  • 1
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Reports Outline Sepsis Study Findings from China-Japan Friendship Hospital (RIPK1 in the inflammatory response and sepsis: Recent advances, drug discovery and beyond)

2023 APR 17 (NewsRx) -- By a News Reporter-Staff News Editor at Blood Daily News -- A new study on sepsis is now available. According

Review Description

Cytokine storms are an important mechanism of sepsis. TNF-α is an important cytokine. As a regulator of TNF superfamily receptors, RIPK1 not only serves as the basis of the scaffold structure in complex I to promote the activation of the NF-κB and MAPK pathways but also represents an important protein in complex II to promote programmed cell death. Ubiquitination of RIPK1 is an important regulatory function that determines the activation of cellular inflammatory pathways or the activation of death pathways. In this paper, we introduce the regulation of RIPK1, RIPK1 PANoptosome’s role in Inflammatory and sepsis, and perspectives.

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