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The SYSCID map: a graphical and computational resource of molecular mechanisms across rheumatoid arthritis, systemic lupus erythematosus and inflammatory bowel disease

Frontiers in Immunology, ISSN: 1664-3224, Vol: 14, Page: 1257321
2023
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    Citations
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    Usage
  • 13
    Captures
  • 1
    Mentions
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    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Captures
    13
  • Mentions
    1
    • News Mentions
      1
      • 1

Most Recent News

University of Luxembourg Researchers Have Provided New Study Findings on Inflammatory Bowel Disease (The SYSCID map: a graphical and computational resource of molecular mechanisms across rheumatoid arthritis, systemic lupus erythematosus and ...)

2023 NOV 10 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Daily -- Investigators publish new report on inflammatory bowel disease.

Article Description

Chronic inflammatory diseases (CIDs), including inflammatory bowel disease (IBD), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are thought to emerge from an impaired complex network of inter- and intracellular biochemical interactions among several proteins and small chemical compounds under strong influence of genetic and environmental factors. CIDs are characterised by shared and disease-specific processes, which is reflected by partially overlapping genetic risk maps and pathogenic cells (e.g., T cells). Their pathogenesis involves a plethora of intracellular pathways. The translation of the research findings on CIDs molecular mechanisms into effective treatments is challenging and may explain the low remission rates despite modern targeted therapies. Modelling CID-related causal interactions as networks allows us to tackle the complexity at a systems level and improve our understanding of the interplay of key pathways. Here we report the construction, description, and initial applications of the SYSCID map (https://syscid.elixir-luxembourg.org/), a mechanistic causal interaction network covering the molecular crosstalk between IBD, RA and SLE. We demonstrate that the map serves as an interactive, graphical review of IBD, RA and SLE molecular mechanisms, and helps to understand the complexity of omics data. Examples of such application are illustrated using transcriptome data from time-series gene expression profiles following anti-TNF treatment and data from genome-wide associations studies that enable us to suggest potential effects to altered pathways and propose possible mechanistic biomarkers of treatment response.

Bibliographic Details

Acencio, Marcio Luis; Ostaszewski, Marek; Mazein, Alexander; Rosenstiel, Philip; Aden, Konrad; Mishra, Neha; Andersen, Vibeke; Sidiropoulos, Prodromos; Banos, Aggelos; Filia, Anastasia; Rahmouni, Souad; Finckh, Axel; Gu, Wei; Schneider, Reinhard; Satagopam, Venkata

Frontiers Media SA

Medicine; Immunology and Microbiology

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