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CAR Immunotherapy for the treatment of infectious diseases: a systematic review

Frontiers in Immunology, ISSN: 1664-3224, Vol: 15, Page: 1289303
2024
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Most Recent News

Hospital Clinico Universitario Lozano Blesa Researchers Add New Study Findings to Research in Infectious Diseases and Conditions (CAR Immunotherapy for the treatment of infectious diseases: a systematic review)

2024 FEB 09 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Daily -- Current study results on infectious diseases and conditions have been

Review Description

Immunotherapy treatments aim to modulate the host’s immune response to either mitigate it in inflammatory/autoimmune disease or enhance it against infection or cancer. Among different immunotherapies reaching clinical application during the last years, chimeric antigen receptor (CAR) immunotherapy has emerged as an effective treatment for cancer where different CAR T cells have already been approved. Yet their use against infectious diseases is an area still relatively poorly explored, albeit with tremendous potential for research and clinical application. Infectious diseases represent a global health challenge, with the escalating threat of antimicrobial resistance underscoring the need for alternative therapeutic approaches. This review aims to systematically evaluate the current applications of CAR immunotherapy in infectious diseases and discuss its potential for future applications. Notably, CAR cell therapies, initially developed for cancer treatment, are gaining recognition as potential remedies for infectious diseases. The review sheds light on significant progress in CAR T cell therapy directed at viral and opportunistic fungal infections.

Bibliographic Details

Morte-Romea, Elena; Pesini, Cecilia; Pellejero-Sagastizábal, Galadriel; Letona-Giménez, Santiago; Martínez-Lostao, Luis; Aranda, Silvia Loscos; Toyas, Carla; Redrado, Sergio; Dolader-Ballesteros, Elena; Arias, Maykel; Galvez, Eva M; Sanz-Pamplona, Rebeca; Pardo, Julián; Paño-Pardo, Jose Ramón; Ramírez-Labrada, Ariel

Frontiers Media SA

Medicine; Immunology and Microbiology

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