The interplay between the microbiota and opioid in the treatment of neuropathic pain
Frontiers in Microbiology, ISSN: 1664-302X, Vol: 15, Page: 1390046
2024
- 2Citations
- 9Captures
- 1Mentions
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Most Recent News
New Findings in Opioids Described from First Affiliated Hospital of Shenzhen University (The interplay between the microbiota and opioid in the treatment of neuropathic pain)
2024 JUN 26 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Daily News -- Research findings on opioids are
Review Description
Neuropathic pain (NP) is characterized by its complex and multifactorial nature and limited responses to opioid therapy; NP is associated with risks of drug resistance, addiction, difficulty in treatment cessation, and psychological disorders. Emerging research on gut microbiota and their metabolites has demonstrated their effectiveness in alleviating NP and augmenting opioid-based pain management, concurrently mitigating the adverse effects of opioids. This review addresses the following key points: (1) the current advances in gut microbiota research and the challenges in using opioids to treat NP, (2) the reciprocal effects and benefits of gut microbiota on NP, and (3) the interaction between opioids with gut microbiota, as well as the benefits of gut microbiota in opioid-based treatment of NP. Through various intricate mechanisms, gut microbiota influences the onset and progression of NP, ultimately enhancing the efficacy of opioids in the management of NP. These insights pave the way for further pragmatic clinical research, ultimately enhancing the efficacy of opioid-based pain management.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85196768819&origin=inward; http://dx.doi.org/10.3389/fmicb.2024.1390046; http://www.ncbi.nlm.nih.gov/pubmed/38919504; https://dx.doi.org/10.3389/fmicb.2024.1390046; https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1390046/full
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