Role of adenosine in the antiepileptic effects of deep brain stimulation
Frontiers in Cellular Neuroscience, ISSN: 1662-5102, Vol: 8, Issue: OCT, Page: 312
2014
- 43Citations
- 67Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations43
- Citation Indexes43
- 43
- CrossRef14
- Captures67
- Readers67
- 67
Article Description
Despite the effectiveness of anterior thalamic nucleus (AN) deep brain stimulation (DBS) for the treatment of epilepsy, mechanisms responsible for the antiepileptic effects of this therapy remain elusive. As adenosine modulates neuronal excitability and seizure activity in animal models, we hypothesized that this nucleoside could be one of the substrates involved in the effects of AN DBS. We applied 5 days of stimulation to rats rendered chronically epileptic by pilocarpine injections and recorded epileptiform activity in hippocampal slices. We found that slices from animals given DBS had reduced hippocampal excitability and were less susceptible to develop ictal activity. In live animals, AN DBS significantly increased adenosine levels in the hippocampus as measured by microdialysis. The reduced excitability of DBS in vitro was completely abolished in animals pre-treated with A1 receptor antagonists and was strongly potentiated by A1 receptor agonists. We conclude that some of the antiepileptic effects of DBS may be mediated by adenosine.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84907654721&origin=inward; http://dx.doi.org/10.3389/fncel.2014.00312; http://www.ncbi.nlm.nih.gov/pubmed/25324724; http://journal.frontiersin.org/article/10.3389/fncel.2014.00312/abstract; https://dx.doi.org/10.3389/fncel.2014.00312; https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2014.00312/full
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