Differential Diagnosis of Multiple System Atrophy-Parkinsonism and Parkinson's Disease Using α-Synuclein and External Anal Sphincter Electromyography
Frontiers in Neurology, ISSN: 1664-2295, Vol: 11, Page: 1043
2020
- 15Citations
- 21Captures
- 1Mentions
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- Citations15
- Citation Indexes15
- 15
- Captures21
- Readers21
- 21
- Mentions1
- News Mentions1
- News1
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Differential Diagnosis of Multiple System Atrophy-Parkinsonism and Parkinson's Disease Using α-Synuclein and External Anal Sphincter Electromyography.
Front Neurol. 2020;11:1043. Epub 2020 Sep 17 Authors: Cao Z, Wu Y, Liu G, Jiang Y, Wang X, Wang Z, Feng T PubMed: 33041984 Submit Comment
Article Description
Background and aim: Discriminating multiple system atrophy-parkinsonism (MSA-P) from Parkinson's disease (PD) is challenging. We aimed to provide a new method to make an identification between MSA-P and PD by combining biofluid marker with electrophysiology marker. Methods: The XYCQ EV Enrichment KIT was applied to extract extracellular vesicles (EVs) from saliva. The levels of α-syn which included total α-syn (α- syn), phosphorylated-ser129 α-syn (α-syn) and oligomeric α-syn (α-syn) in EVs of saliva were tested by new developed Electrochemiluminescence (ECL) assays. We collected multi-motor unit potential (MUP) of all participants who conducted external anal sphincter electromyography (EAS-EMG). The duration, phase, amplitude and satellite potential of EAS-EMG were analyzed. The Receiver operator characteristic (ROC) curve was adopted to analyze the diagnostic utility of α-syn in EVs of saliva, EAS-EMG for MSA-P. Results: In EVs of saliva, the α-syn concentrations were lower in MSA-P than PD (P = 0.003). No significant difference was shown in α-syn and α-syn. α-syn 4.46 pg/ng distinguished MSA-P from PD with area under the curve (AUC) 0.804. Compared with PD, the duration, phase and satellite potential of EAS-EMG in MSA-P were increased (P = 0.002, 0.008, 0.001). There was no significant difference in amplitude. ROC curve showed that the duration (AUC: 0.780), phase (AUC: 0.751), and satellite potential (AUC: 0.809) had both diagnostic value for MSA-P. The combination of α-syn in salivary EVs and EAS-EMG (including duration, phase and satellite potential) could efficiently make a differentiation between MSA-P and PD with sensitivity of 100% and specificity of 86%. The AUC value was 0.901. Conclusion: The study suggested the combination of α-syn in salivary EVs and EAS-EMG could help efficiently distinguish MSA-P from PD.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85091924812&origin=inward; http://dx.doi.org/10.3389/fneur.2020.01043; http://www.ncbi.nlm.nih.gov/pubmed/33041984; https://www.frontiersin.org/article/10.3389/fneur.2020.01043/full; https://www.frontiersin.org/articles/10.3389/fneur.2020.01043/supplementary-material/10.3389/fneur.2020.01043.s001; http://dx.doi.org/10.3389/fneur.2020.01043.s001; https://dx.doi.org/10.3389/fneur.2020.01043; https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2020.01043/full; https://dx.doi.org/10.3389/fneur.2020.01043.s001
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