The emerging roles of ferroptosis in cells of the central nervous system
Frontiers in Neuroscience, ISSN: 1662-453X, Vol: 16, Page: 1032140
2022
- 14Citations
- 35Captures
- 1Mentions
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Metrics Details
- Citations14
- Citation Indexes14
- 14
- Captures35
- Readers35
- 35
- Mentions1
- News Mentions1
- News1
Most Recent News
West China Second University Hospital Researchers Describe Research in Central Nervous System Disorders (The emerging roles of ferroptosis in cells of the central nervous system)
2022 DEC 23 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Daily -- Research findings on central nervous system disorders are
Review Description
Ferroptosis is morphologically characterized by shrunken mitochondria and biochemically characterized by iron overload, lipid peroxidation and lipid reactive oxygen species (ROS) accumulation; these phenomena are suppressed by iron chelation, genetic inhibition of cellular iron uptake, and intervention on other pathways such as lipid metabolism. The induction of ferroptosis may be related to pathological cellular conditions in the central nervous system (CNS); thus, ferroptosis may cause disability via CNS damage. Here, we review the role of ferroptosis in the main cells of the CNS, including glial cells, neurons, and pericytes; in various diseases of the CNS; and in the interaction of glia and neurons in CNS diseases. Some small molecules and traditional Chinese drugs which inhibit ferroptosis in cells of the CNS are shown as potential therapeutic strategies for neurological diseases.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85145023117&origin=inward; http://dx.doi.org/10.3389/fnins.2022.1032140; http://www.ncbi.nlm.nih.gov/pubmed/36590286; https://www.frontiersin.org/articles/10.3389/fnins.2022.1032140/full; https://dx.doi.org/10.3389/fnins.2022.1032140; https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2022.1032140/full
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