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Brain-Derived Neurotrophic Factor: A Connecting Link Between Nutrition, Lifestyle, and Alzheimer’s Disease

Frontiers in Neuroscience, ISSN: 1662-453X, Vol: 16, Page: 925991
2022
  • 21
    Citations
  • 0
    Usage
  • 71
    Captures
  • 1
    Mentions
  • 8
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    21
  • Captures
    71
  • Mentions
    1
    • News Mentions
      1
      • News
        1
  • Social Media
    8
    • Shares, Likes & Comments
      8
      • Facebook
        8

Most Recent News

Brain-Derived Neurotrophic Factor: A Connecting Link Between Nutrition, Lifestyle, and Alzheimer's Disease.

Front Neurosci. 2022;16:925991. Epub 2022 May 25 Authors: Xue B, Waseem SM, Zhu Z, Alshahrani MA, Nazam N, Anjum F, Habib AH, Rafeeq MM, Nazam F, Sharma M PubMed: 35692417 Submit Comment

Review Description

Brain-derived neurotrophic factor (BDNF) involving tropomyosin kinase B and low affinity p75 neurotropin receptors is the most abundant and researched neurotropins in mammal’s brain. It is one of the potential targets for therapeutics in Alzheimer’s disease (AD) owing to its key role in synaptic plasticity. Low levels of BDNF are implicated in the pathophysiology of neurological diseases including AD. However, a healthy lifestyle, exercise, and dietary modifications are shown to positively influence insulin regulation in the brain, reduce inflammation, and up-regulate the levels of BDNF, and are thus expected to have roles in AD. In this review, the relationship between BDNF, mental health, and AD is discussed. Insights into the interrelationships between nutrition, lifestyle, and environment with BDNF and possible roles in AD are also provided in the review. The review sheds light on the possible new therapeutic targets in neurodegenerative diseases.

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