Tracking Response Dynamics of Sequential Working Memory in Patients With Mild Parkinson’s Disease
Frontiers in Psychology, ISSN: 1664-1078, Vol: 12, Page: 631672
2021
- 3Citations
- 14Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations3
- Citation Indexes3
- Captures14
- Readers14
- 14
Article Description
The ability to sequence thoughts and actions is impaired in Parkinson’s disease (PD). In PD, a distinct error pattern has been found in the offline performance of sequential working memory. This study examined how PD’s performance of sequential working memory unfolds over time using mouse tracking techniques. Non-demented patients with mild PD (N = 40) and healthy controls (N = 40) completed a computerized digit ordering task with a computer mouse. We measured response dynamics in terms of the initiation time, ordering time, movement time, and area under the movement trajectory curve. This approach allowed us to distinguish between the cognitive processes related to sequence processing before the actual movement (initiation time and ordering time) and the execution processes of the actual movement (movement time and area under the curve). PD patients showed longer initiation times, longer movement times, and more constrained movement trajectories than healthy controls. The initiation time and ordering time negatively correlated with the daily exposure to levodopa and D2/3 receptor agonists, respectively. The movement time positively correlated with the severity of motor symptoms. We demonstrated an altered temporal profile of sequential working memory in PD. Stimulating D1 and D2/3 receptors might speed up the maintenance and manipulation of sequences, respectively.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85102137073&origin=inward; http://dx.doi.org/10.3389/fpsyg.2021.631672; http://www.ncbi.nlm.nih.gov/pubmed/33679559; https://www.frontiersin.org/articles/10.3389/fpsyg.2021.631672/supplementary-material/10.3389/fpsyg.2021.631672.s001; http://dx.doi.org/10.3389/fpsyg.2021.631672.s001; https://www.frontiersin.org/articles/10.3389/fpsyg.2021.631672/full; https://dx.doi.org/10.3389/fpsyg.2021.631672; https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2021.631672/full; https://dx.doi.org/10.3389/fpsyg.2021.631672.s001
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