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An alternative method of SNP inclusion to develop a generalized polygenic risk score analysis across Alzheimer's disease cohorts.

Frontiers in dementia, ISSN: 2813-3919, Vol: 2, Page: 1120206
2023
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An alternative method of SNP inclusion to develop a generalized polygenic risk score analysis across Alzheimer's disease cohorts.

Front Dement. 2023;2:1120206. Epub 2023 Jul 31 Authors: Brookes KJ, Guetta-Baranes T, Thomas A, Morgan K PubMed: 39081983 Submit Comment

Article Description

Polygenic risk scores (PRSs) have great clinical potential for detecting late-onset diseases such as Alzheimer's disease (AD), allowing the identification of those most at risk years before the symptoms present. Although many studies use various and complicated machine learning algorithms to determine the best discriminatory values for PRSs, few studies look at the commonality of the Single Nucleotide Polymorphisms (SNPs) utilized in these models.

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