PlumX Metrics
Embed PlumX Metrics

The Antioxidant Properties of Lavandula multifida Extract Contribute to Its Beneficial Effects in High-Fat Diet-Induced Obesity in Mice

Antioxidants, ISSN: 2076-3921, Vol: 12, Issue: 4
2023
  • 5
    Citations
  • 0
    Usage
  • 11
    Captures
  • 0
    Mentions
  • 3
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    5
    • Citation Indexes
      5
  • Captures
    11
  • Social Media
    3
    • Shares, Likes & Comments
      3
      • Facebook
        3

Article Description

Obesity is a worldwide public health problem whose prevalence rate has increased steadily over the last few years. Therefore, it is urgent to improve the management of obesity and its comorbidities, and plant-based treatments are receiving increasing attention worldwide. In this regard, the present study aimed to investigate a well-characterized extract of Lavandula multifida (LME) in an experimental model of obesity in mice and explore the underlying mechanisms. Interestingly, the daily administration of LME reduced weight gain as well as improved insulin sensitivity and glucose tolerance. Additionally, LME ameliorated the inflammatory state in both liver and adipose tissue by decreasing the expression of various proinflammatory mediators (Il-6, Tnf-α, Il-1β, Jnk-1, Pparα, Pparγ, and Ampk) and prevented increased gut permeability by regulating the expression of mucins (Muc-1, Muc-2, and Muc-3) and proteins implicated in epithelial barrier integrity maintenance (Ocln, Tjp1, and Tff-3). In addition, LME showed the ability to reduce oxidative stress by inhibiting nitrite production on macrophages and lipid peroxidation. These results suggest that LME may represent a promising complementary approach for the management of obesity and its comorbidities.

Bibliographic Details

Molina-Tijeras, Jose Alberto; Ruiz-Malagón, Antonio Jesús; Hidalgo-García, Laura; Diez-Echave, Patricia; Rodríguez-Sojo, María Jesús; Cádiz-Gurrea, María de la Luz; Segura-Carretero, Antonio; Del Palacio, José Pérez; González-Tejero, María Reyes; Rodríguez-Cabezas, María Elena; Gálvez, Julio; Rodríguez-Nogales, Alba; Vezza, Teresa; Algieri, Francesca

MDPI AG

Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know