Effects of Oxidized Pyrenes on the Biological Responses in the Human Bronchial Epithelial Cells
Applied Sciences (Switzerland), ISSN: 2076-3417, Vol: 12, Issue: 19
2022
- 2Citations
- 3Captures
- 1Mentions
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Although polycyclic aromatic hydrocarbons (PAHs) are toxic, the effects of oxidized PAHs on health and biological responses remain unclear. In this study, we examined the in vitro effects of varying concentrations of pyrene, a type of PAH, and its quinone forms, namely 4,5-pyrenequinone (PyQ) and 1,8-PyQ + 1,6-PyQ, on human lung epithelial (BEAS-2B) cells. We evaluated cell viability, apoptosis, and the production of interleukin (IL)-6, IL-8, soluble intercellular adhesion molecule-1 (sICAM-1), and reactive oxygen species (ROS). Exposure to 1 μM 4,5-PyQ or 1,8-PyQ + 1,6-PyQ increased the cellular activity. At 3 µM, 4,5-PyQ increased the number of late apoptotic and/or necrotic cells compared with those in the control, whereas 1,8-PyQ + 1,6-PyQ increased the number of dead cells. Exposure to 4,5-PyQ at 10 µM decreased IL-6 production and exposure to both 4,5-PyQ and 1,8-PyQ + 1,6-PyQ at 3 or 10 µM decreased IL-8 production. sICAM-1 production was increased after 1,8-PyQ + 1,6-PyQ exposure at 10 µM. In the presence of cells, 4,5-PyQ and 1,8-PyQ + 1,6-PyQ increased ROS production significantly in a concentration-dependent manner; similar results were observed with 1,8-PyQ + 1,6-PyQ without cells. Overall, our results suggest that oxidized PAHs induce stronger respiratory toxicity/inflammatory responses than PAHs.
Bibliographic Details
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know