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Personalized Setup Optimization Strategies to Improve Clinical Workflow in Image-Guided Pediatric Particle Therapy

Applied Sciences (Switzerland), ISSN: 2076-3417, Vol: 14, Issue: 11
2024
  • 0
    Citations
  • 0
    Usage
  • 10
    Captures
  • 2
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Captures
    10
  • Mentions
    2
    • Blog Mentions
      1
      • Blog
        1
    • News Mentions
      1
      • News
        1

Most Recent News

Data on Applied Sciences Published by a Researcher at Bioengineering Unit (Personalized Setup Optimization Strategies to Improve Clinical Workflow in Image-Guided Pediatric Particle Therapy)

2024 JUN 13 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Science Daily -- Investigators publish new report on applied sciences. According to

Article Description

Featured Application: Setup optimization in pediatric particle therapy. The purpose of this retrospective study was to simulate a daily pre-alignment strategy to mitigate systematic positioning errors in image-guided pediatric hadron therapy. All pediatric patients (32 patients, 853 fractions) treated from December 2021 and September 2022 at our Institution were retrospectively considered. For all fractions, daily correction vectors (CVs) resulting from image registration for patient positioning were retrieved in the form of txt files from the hospital database. For each fraction, an adjusted correction vector (V′) was then computed as the difference between the actual one (V) and the algebraic average of the previous ones, as to simulate patient pre-alignment before imaging. The Euclidean norm of each V′ was computed and normalized with respect to that of the corresponding V to derive N. Pre-correcting all the coordinate values led to a 46% average reduction (min 20%, max 60%) in CVs, considering the first 27 fractions (average value in this cohort of patients). Such a potential improvement (N < 1) was observed for the most patients’ fractions (781/853, 91.6%). For the remaining 72/853 cases (8.4%), a remarkable worsening (N > 2) involved only 7/853 (0.82%) fractions. The presented strategy shows promising outcomes in order to ameliorate pediatric patient setup before imaging. However, further investigations to identify patients most likely to benefit from this approach are warranted.

Bibliographic Details

Matteo Pepa; Andrea Pella; Giulia Sellaro; Federica Galante; Guido Baroni; Alfredo Mirandola; Mario Ciocca; Angelica Ghirelli; Francesca Colombo; Alberto Iannalfi; Ester Orlandi; Sabina Vennarini; Sara Imparato; Chiara Paganelli

MDPI AG

Materials Science; Physics and Astronomy; Engineering; Chemical Engineering; Computer Science

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