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Plant-Derived Bioactive Compounds in Colorectal Cancer: Insights from Combined Regimens with Conventional Chemotherapy to Overcome Drug-Resistance

Biomedicines, ISSN: 2227-9059, Vol: 10, Issue: 8
2022
  • 28
    Citations
  • 0
    Usage
  • 29
    Captures
  • 1
    Mentions
  • 1
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    28
  • Captures
    29
  • Mentions
    1
    • Blog Mentions
      1
      • Blog
        1
  • Social Media
    1
    • Shares, Likes & Comments
      1
      • Facebook
        1

Most Recent Blog

Biomedicines, Vol. 10, Pages 1948: Plant-Derived Bioactive Compounds in Colorectal Cancer: Insights from Combined Regimens with Conventional Chemotherapy to Overcome Drug-Resistance

Biomedicines, Vol. 10, Pages 1948: Plant-Derived Bioactive Compounds in Colorectal Cancer: Insights from Combined Regimens with Conventional Chemotherapy to Overcome Drug-Resistance Biomedicines doi: 10.3390/biomedicines10081948 Authors:

Review Description

Acquired drug resistance represents a major clinical problem and one of the biggest limitations of chemotherapeutic regimens in colorectal cancer. Combination regimens using standard chemotherapeutic agents, together with bioactive natural compounds derived from diet or plants, may be one of the most valuable strategies to overcome drug resistance and re-sensitize chemoresistant cells. In this review, we highlight the effect of combined regimens based on conventional chemotherapeutics in conjunction with well-tolerated plant-derived bioactive compounds, mainly curcumin, resveratrol, and EGCG, with emphasis on the molecular mechanisms associated with the acquired drug resistance.

Bibliographic Details

Gavrilas, Laura Ioana; Cruceriu, Daniel; Mocan, Andrei; Loghin, Felicia; Miere, Doina; Balacescu, Ovidiu

MDPI AG

Medicine; Biochemistry, Genetics and Molecular Biology

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