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A guide for water bolus temperature selection for semi-deep head and neck hyperthermia treatments using the hypercollar3d applicator

Cancers, ISSN: 2072-6694, Vol: 13, Issue: 23
2021
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Article Description

During hyperthermia cancer treatments, especially in semi-deep hyperthermia in the head and neck (H&N) region, the induced temperature pattern is the result of a complex interplay between energy delivery and tissue cooling. The purpose of this study was to establish a water bolus temperature guide for the HYPERcollar3D H&N applicator. First, we measured the HYPERcollar3D water bolus heat-transfer coefficient. Then, for 20 H&N patients and phase/amplitude settings of 93 treatments we predict the T50 for nine heat-transfer coefficients and ten water bolus temperatures ranging from 20–42.5C. Total power was always tuned to obtain a maximum of 44C in healthy tissue in all simulations. As a sensitivity study we used constant and temperature-dependent tissue cooling properties. We measured a mean heat-transfer coefficient of h = 292 W mK for the HYPERcollar3D water bolus. The predicted T50 shows that temperature coverage is more sensitive to the water bolus temperature than to the heat-transfer coefficient. We propose changing the water bolus temperature from 30C to 35C which leads to a predicted T50 increase of +0.17/+0.55C (constant/temperature-dependent) for targets with a median depth < 20 mm from the skin surface. For deeper targets, maintaining a water bolus temperature at 30C is proposed.

Bibliographic Details

Drizdal, Tomas; van Rhoon, Gerard C; Verhaart, Rene F; Fiser, Ondrej; Paulides, Margarethus M

MDPI AG

Medicine; Biochemistry, Genetics and Molecular Biology

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