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Nonsurgical Treatment Strategies for Elderly Head and Neck Cancer Patients: An Emerging Subject Worldwide

Cancers, ISSN: 2072-6694, Vol: 14, Issue: 22
2022
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Most Recent News

Reports from Gifu University Graduate School of Medicine Add New Study Findings to Research in Head and Neck Cancer (Nonsurgical Treatment Strategies for Elderly Head and Neck Cancer Patients: An Emerging Subject Worldwide)

2022 DEC 09 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Gene Therapy Daily -- New study results on head and neck cancer

Review Description

Consistent with the increasing rate of head and neck cancers among elderly adults, there has been an increase in the rate of those receiving nonsurgical treatments to maintain their function and quality of life. However, various problems, such as poor tolerance to chemoradiotherapy-related toxicity, are of greater concern in elderly adults than in younger individuals. In this review, we describe adverse events that should be particularly noted in elderly patients and provide an overview of countermeasures in nonsurgical treatments. We mainly focus on cisplatin-based chemoradiotherapy—the primary treatment for head and neck squamous cell carcinoma (HNSCC). Furthermore, we review the molecular targeted drugs and immune checkpoint inhibitors for elderly patients with HNSCC. Although the number of older patients is increasing worldwide, clinical trials aimed at determining the standard of care typically enroll younger or well-conditioned elderly patients. There is still very little evidence for treating elderly HNSCC older patients, and the question of optimal treatment needs to be explored.

Bibliographic Details

Okuda, Hiroshi; Shibata, Hirofumi; Watanabe, Takahiro; Terazawa, Kosuke; Mori, Kenichi; Ueda, Natsuko; Ohashi, Toshimitsu; Ogawa, Takenori

MDPI AG

Medicine; Biochemistry, Genetics and Molecular Biology

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