Lipase-catalyzed synthesis of indolyl 4H-chromenes via a multicomponent reaction in ionic liquid
Catalysts, ISSN: 2073-4344, Vol: 7, Issue: 6
2017
- 28Citations
- 19Captures
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Article Description
Synthesis of indolyl 4H-chromenes via a three-component reaction catalyzed by lipase in ionic liquidsis reported here for the first time. High yields (77–98%) were obtained when Mucor miehei lipase was used as the catalyst in [EMIM][BF4]. Furthermore, [EMIM][BF4] exhibited good reusability in this enzymatic reaction. This study affords a new example of lipase catalytic promiscuity and broadens the application range of ionic liquid in biocatalysis.
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