TGFβ and the Tumor Microenvironment in Colorectal Cancer
Cells, ISSN: 2073-4409, Vol: 12, Issue: 8
2023
- 11Citations
- 23Captures
- 3Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations11
- Citation Indexes11
- 11
- Captures23
- Readers23
- 23
- Mentions3
- News Mentions2
- News2
- Blog Mentions1
- Blog1
Most Recent News
Reports Summarize Colon Cancer Study Results from Friedrich-Alexander-University Erlangen-Nurnberg (FAU) (Tgf Beta and the Tumor Microenvironment In Colorectal Cancer)
2023 JUL 03 (NewsRx) -- By a News Reporter-Staff News Editor at Gastroenterology Daily News -- New research on Oncology - Colon Cancer is the
Review Description
Growing evidence supports an important role of the tumor microenvironment (TME) in the pathogenesis of colorectal cancer (CRC). Resident cells such as fibroblasts or immune cells infiltrating into the TME maintain continuous crosstalk with cancer cells and thereby regulate CRC progression. One of the most important molecules involved is the immunoregulatory cytokine transforming growth factor-β (TGFβ). TGFβ is released by various cells in the TME, including macrophages and fibroblasts, and it modulates cancer cell growth, differentiation, and cell death. Mutations in components of the TGF pathway, including TGFβ receptor type 2 or SMAD4, are among the most frequently detected mutations in CRC and have been associated with the clinical course of disease. Within this review, we will discuss our current understanding about the role of TGFβ in the pathogenesis of CRC. This includes novel data on the molecular mechanisms of TGFβ signaling in TME, as well as possible strategies for CRC therapy targeting the TGFβ pathway, including potential combinations with immune checkpoint inhibitors.
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