Salivary Biomarkers for Parkinson’s Disease: A Systematic Review with Meta-Analysis
Cells, ISSN: 2073-4409, Vol: 13, Issue: 4
2024
- 5Citations
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- 3Mentions
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Most Recent News
Poznan University of Medical Sciences Researcher Reports Recent Findings in Parkinson's Disease (Salivary Biomarkers for Parkinson's Disease: A Systematic Review with Meta-Analysis)
2024 FEB 29 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Daily News -- Researchers detail new data in
Review Description
Parkinson’s Disease (PD) is a common neurodegenerative disease which manifests with motor features, such as bradykinesia, resting tremor, rigidity, and postural instability. Using the non-invasive technique of saliva collection, we designed a systematic review to answer the question “Are salivary biomarkers reliable for the diagnosis of Parkinson’s Disease?”. Following inclusion and exclusion criteria, 30 studies were included in this systematic review (according to the PRISMA statement guidelines). Mostly proteins were reported as potential biomarkers in saliva. Based on meta-analysis, in PD patients, salivary levels of total alpha-synuclein were significantly decreased, and those of oligomeric alpha-synuclein were significantly increased. Also, according to pooled AUC, heme oxygenase-1 demonstrated significant predictive value for saliva-based PD diagnosis. In conclusion, some potential biomarkers, especially alpha-synuclein, can be altered in the saliva of PD patients, which could be reliably useful for early diagnosis of this neurodegenerative disease differentiating other synucleopathies.
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